The attack comes days before the sixth round of nuclear negotiations between Tehran and Washington
Israel announced a "preemptive" strike in Iran on Friday and declared a state of emergency in anticipation of retaliation.
A number of loud explosions were reported in Tehran, along with missile interceptions.
The IDF said it targeted both military and nuclear sites. Israeli Prime Minister Benjamin Netanyahu stated that a nuclear enrichment facility in Natanz was among the targets.
News organizations reported last month that Israel had discussed potential strikes on Iranian nuclear sites with the US.
The attack comes after five rounds of US-Iranian talks on Iran's nuclear program failed to produce a breakthrough. The sixth round of negotiations is scheduled for Sunday in Oman.
